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Heterogeneous nature of HIV‐1 recombinants spreading in Spain

Identifieur interne : 000E93 ( Main/Exploration ); précédent : 000E92; suivant : 000E94

Heterogeneous nature of HIV‐1 recombinants spreading in Spain

Auteurs : Africa Holguín [Espagne] ; Amparo Álvarez [Espagne] ; Vincent Soriano [Espagne]

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2005-03.

RBID : ISTEX:A4AD0652FD3803B5BC581519B44A87DB7255FE1C

Descripteurs français

Wicri :
- geographic : Liberia, Espagne.
- topic : Dynamique de la population.

English descriptors

Abstract

HIV‐1 infections due to non‐B subtypes are increasing rapidly in number and spreading across Europe. The genetic nature of HIV‐1 non‐B variants containing subtype G sequences at the protease (PR)‐coding region are described from 48 unrelated subjects living in Spain. Phylogenetic analyses of the HIV‐1 reverse transcriptase (RT) and envelope (env) genes (including the V3 loop) were performed. Up to 32 (66.6%) of samples carried inter‐subtype recombinant viruses. Although double recombinants were found most frequently (G/A in 20; G/B in 8; G/K in 2), two individuals harbored triple recombinant viruses (GPR/BRT/Aenv and GPR/KRT/Aenv, respectively). Only 33 (68.7%) and 9 (18.7%) sequences clustered with clade G when examining the RT and env genes, respectively. Nearly 70% of samples with pol sequences (PR/RT) belonging to subtype G harbored env sequences ascribed to other clades: A (55.6%), B (11.1%), or K (3.7%). Of note, most recombinant viruses clustered with CRF02_AG, although CRF14_BG recombinants were also found. This study demonstrates that most viruses circulating in Spain with clade G sequences at the pol‐coding region are in fact inter‐subtype recombinants, with CRF02_AG being the most prevalent virus. J. Med. Virol. 75:374–380, 2005. © 2005 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/document/A4AD0652FD3803B5BC581519B44A87DB7255FE1C/fulltext/pdf

DOI: 10.1002/jmv.20280

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">HIV‐1 infections due to non‐B subtypes are increasing rapidly in number and spreading across Europe. The genetic nature of HIV‐1 non‐B variants containing subtype G sequences at the protease (PR)‐coding region are described from 48 unrelated subjects living in Spain. Phylogenetic analyses of the HIV‐1 reverse transcriptase (RT) and envelope (env) genes (including the V3 loop) were performed. Up to 32 (66.6%) of samples carried inter‐subtype recombinant viruses. Although double recombinants were found most frequently (G/A in 20; G/B in 8; G/K in 2), two individuals harbored triple recombinant viruses (GPR/BRT/Aenv and GPR/KRT/Aenv, respectively). Only 33 (68.7%) and 9 (18.7%) sequences clustered with clade G when examining the RT and env genes, respectively. Nearly 70% of samples with pol sequences (PR/RT) belonging to subtype G harbored env sequences ascribed to other clades: A (55.6%), B (11.1%), or K (3.7%). Of note, most recombinant viruses clustered with CRF02_AG, although CRF14_BG recombinants were also found. This study demonstrates that most viruses circulating in Spain with clade G sequences at the pol‐coding region are in fact inter‐subtype recombinants, with CRF02_AG being the most prevalent virus. J. Med. Virol. 75:374–380, 2005. © 2005 Wiley‐Liss, Inc.</div>
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Heterogeneous nature of HIV‐1 recombinants spreading in Spain

Heterogeneous nature of HIV‐1 recombinants spreading in Spain

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri